Apigenin

Product Description

Apigenin is a premier flavonoid, celebrated as one of the primary soothing compounds found in chamomile, and a multi-functional active for advanced skin and hair care. Its primary value lies in its exceptional anti-inflammatory and antioxidant properties, making it a gold-standard ingredient for calming sensitive, irritated skin and protecting it from environmental stressors. Beyond skin soothing, Apigenin is a key active in advanced hair care, where it functions as a vasodilator to improve microcirculation to the scalp, supporting healthy hair follicle function and vitality. For brands developing high-performance solutions for sensitive skin, or innovative treatments for scalp and hair health, our high-purity Apigenin is an essential, science-backed natural active.

Product Uses

• Soothing & Sensitive Skincare: The hero active in calming serums, creams for redness-prone skin, post-procedure treatments, and gentle formulations for sensitive skin.
• Scalp & Hair Care: A critical component in anti-hair loss serums and scalp tonics (often in combination with peptides and oleanolic acid) to support a healthy scalp environment and fortify hair follicles by improving nutrient delivery.
• Anti-Pollution & Daily Defense: Used in daily-wear products to provide a powerful antioxidant shield against free radical damage from UV and pollution.
• Baby Care & Delicate Skin: Its strong safety profile and soothing action make it suitable for gentle formulations for babies and delicate skin.

Formulation Suggestions

Recommended dosage: 0.05% - 0.2%.
Apigenin's efficacy is matched by its significant formulation challenges, primarily its poor solubility in water and high sensitivity to light and oxidation. Direct incorporation into aqueous systems is not feasible. For effective delivery, it must be pre-dissolved in a suitable solvent system (e.g., a blend of glycols like Propanediol, Ethanol, and solubilizers) or utilized via an advanced delivery system like liposomal encapsulation. To prevent degradation and discoloration, formulate at a slightly acidic pH (4.5-6.0) and use robust secondary antioxidants, chelating agents, and fully opaque, airless packaging.

Our advice is for reference only. Please follow the recommendations of your formulator for actual production.

Product Specification

• INCI Name: Apigenin
• Synonyms: 4′,5,7-Trihydroxyflavone
• CAS No.: 520-36-5
• Molecular Formula: C₁₅H₁₀O₅
• Appearance: Yellow crystalline powder
• Purity: ≥98% (by HPLC)
• Solubility: Insoluble in water. Soluble in Ethanol, DMSO. Requires advanced delivery systems or specific solvent systems for cosmetic use.
• Stability: Highly sensitive to light, oxygen, and high pH. Requires a protected formulation and light-proof packaging.
• Properties: Potent Anti-inflammatory, Soothing Agent, Powerful Antioxidant, Microcirculation Support (Vasodilator).
• Origin: China