Fisetin

Product Description

Fisetin is a cutting-edge, plant-derived flavonoid at the forefront of "senolytic" anti-aging technology. It offers a revolutionary approach to skin rejuvenation by selectively targeting and helping to clear senescent "zombie" cells. These aging cells contribute to inflammation and degrade the skin's matrix. By removing them, Fisetin promotes a healthier cellular environment and supports true skin renewal. Its key advantage is this unique "cellular cleanup" mechanism, which goes beyond traditional anti-aging. For formulators developing next-generation, science-driven products that target aging at its root, Fisetin is an indispensable and powerful active ingredient.

Product Uses

This advanced active is a cornerstone for the most sophisticated and high-performance anti-aging formulations:

• Anti-Aging: The ideal hero ingredient for cellular-rejuvenation serums, "longevity" creams, and intensive treatments targeting deep-set signs of aging.
• Protective Skincare: A key component in "anti-glycation" formulas and daily-use products designed to protect the skin from environmental and photo-damage.
• Brightening Products: Its anti-inflammatory and antioxidant properties help to improve skin clarity and radiance.

Formulation Suggestions

The recommended dosage is between 0.1-1.0%. As a powder with poor water solubility, Fisetin must be pre-dissolved in a suitable solvent system, such as a blend of glycols (e.g., pentylene glycol) and ethanol, before being added to a formulation. It is best incorporated into the oil phase of an emulsion or into anhydrous systems. To ensure stability, the final formulation's pH should be kept in the acidic range (pH < 5.0) and opaque, airless packaging is highly recommended.

Our advice is for reference only. Please follow the recommendations of your formulator for actual production.

Product Specification

• INCI Name: Fisetin
• Synonyms: 3,3',4',7-Tetrahydroxyflavone
• CAS No.: 528-48-3
• Molecular Formula: C₁₅H₁₀O₆
• Appearance: Yellow crystalline powder
• Purity: ≥98%
• Solubility: Soluble in ethanol and glycols. Insoluble in water.
• Stability: Stable in solid form. In formulations, protect from light and high pH to prevent degradation and color change.
• Properties: A potent senolytic agent that helps to clear senescent "zombie" cells, making way for cellular renewal. It is a powerful antioxidant, an anti-glycation agent that protects collagen, and has strong anti-inflammatory and photoprotective properties.
• Origin: China