Hydroxyphenyl Propamidobenzoic Acid

Product Description

Hydroxyphenyl Propamidobenzoic Acid is a powerful, synthetic soothing agent inspired by the active avenanthramides found naturally in oats. Developed through advanced pharmaceutical-grade synthesis, this biomimetic ingredient is specifically engineered to target the root causes of skin sensitivity and irritation. It acts as a highly potent anti-irritant by inhibiting the release of histamines and pro-inflammatory cytokines. This ingredient is a premium B2B asset for formulators looking to create high-performance "rescue" treatments, providing rapid relief from itching, redness, and environmental stress with scientifically proven efficacy at very low concentrations.

Product Specification

• INCI Name: Hydroxyphenyl Propamidobenzoic Acid
• CAS No.: 697235-49-7
• Chemical Name: 2-[3-(4-hydroxyphenyl)propanoylamino]benzoic acid
• Product Type: Anti-irritant / Soothing Agent / Active
• Appearance: White to off-white crystalline powder (often supplied in a glycol solution for ease of use)
• Purity (HPLC): ≥ 98.0%
• Recommended Use Level: 0.1% – 5.0% (depending on solution concentration)
• Solubility: Soluble in glycols (e.g., Pentylene Glycol, Butylene Glycol); insoluble in water.

Key Benefits & Applications

• Rapid Anti-Itch Efficacy: Significantly reduces itching sensations and neurogenic inflammation, making it ideal for eczema-prone or hyper-reactive skin.
• Powerful Anti-Redness: Effectively calms skin erythema caused by UV exposure, chemical peels, or mechanical stress.
• Biomimetic Safety: Mimics the natural soothing properties of oats but with higher purity, stability, and standardized potency compared to natural extracts.
• Histamine Inhibition: Acts as a potent antihistamine-like cosmetic active to block the cascade of allergic skin reactions.
• Applications: High-end sensitive skin creams, after-sun lotions, post-shave balms, scalp soothing serums, and anti-itch body care.

Formulation Guidelines

• Suggested Dosage: 0.5% – 2.0% for standard soothing; up to 5.0% for intensive repair products.
• pH Stability: Optimal performance and stability are achieved within a pH range of 4.0 – 7.5.
• Processing: If using the powder form, pre-dissolve in a glycol (like Pentylene Glycol) before adding to the formulation. Add during the cool-down phase (below 40°C) to ensure maximum activity.
• Color Stability: Avoid exposure to strong oxidizing agents and direct sunlight, as phenolic compounds may cause slight color shifts over time.
• Synergy: Combine with Bisabolol to provide a multi-pathway soothing effect that targets both cellular inflammation and surface sensitivity.