Madecassic Acid

Product Description

As a dedicated wholesale supplier of high-purity Centella isolates, we provide High Purity Madecassic Acid (≥98%) at competitive factory-direct prices. This bioactive ingredient is a specific triterpene aglycone derived from Centella Asiatica. Unlike its glycoside counterpart (Madecassoside), Madecassic Acid is a lipophilic molecule, allowing it to integrate more effectively into the skin's lipid bilayers. Known as the "Fire Extinguisher" of the Cica family, it is scientifically valued for its superior bioavailability and its ability to rapidly downregulate inflammatory mediators.

Our ≥98.0% crystalline isolate is engineered for professional dermo-cosmetic applications where intensive soothing and structural repair are required. We ensure wholesale & bulk supply consistency for manufacturers focusing on anhydrous repair balms, post-procedure recovery systems, and high-performance "SOS" facial oils.

Product Specification

• INCI Name: Madecassic Acid
• CAS No.: 18449-41-7
• Botanical Source: Centella Asiatica (Gotu Kola)
• Part Used: Dried Leaf
• Appearance: White to off-white crystalline powder
• Active Marker (HPLC): ≥98.0% (High Purity Isolate)
• Solubility: Soluble in Ethanol, Glycols (Propylene Glycol), and warm lipids; Insoluble in water
• Extraction Method: Refined multi-stage isolation and purification
• Grade: Cosmetic Grade (Pharma-grade purity)
• Origin: China (Direct Factory Supply)

Key Benefits & Applications

• Intensive Inflammation Control: Directly inhibits the release of pro-inflammatory cytokines such as IL-1α and IL-8, providing immediate physiological relief for red, irritated, or compromised skin.
• Lipid Barrier Reconstruction: Works within the stratum corneum to reinforce the skin's lipid matrix, making it crucial for treating atopic dermatitis or chronically dry skin.
• Filaggrin Synthesis Stimulation: Promotes the expression of filaggrin, a critical protein responsible for maintaining skin hydration and structural integrity.
• Dermal Repair Enhancement: Supports the natural healing process by protecting the extracellular matrix from degradation under inflammatory stress.
• Applications: Essential for anhydrous repair balms, post-laser recovery creams, specialized "SOS" treatment oils, and barrier-strengthening emulsions.

Formulation Guidelines

• Recommended Dosage: 0.1% – 0.5% (Extremely potent triterpene active).
• Incorporation (Temp/Phase/Solvent): Lipophilic nature. Must be pre-dissolved in glycols (Propylene/Butylene Glycol) or ethanol. Alternatively, disperse into the hot oil phase (above 75°C) during the emulsification process. Do not add directly to the water phase.
• pH Stability: Optimal stability within pH range 5.0 – 7.0.
• Compatibility/Stability Notes: Highly stable in oil-rich and waterless formulations. Protect from light and moisture to maintain crystalline purity.
• Synergy: Combine with Asiatic Acid and Asiaticoside to recreate the synergistic efficacy of TECA (Titrated Extract of Centella Asiatica) for pharmaceutical-grade skin regeneration.