Methylisothiazolinone

Product Description

Our high-purity Methylisothiazolinone (MIT) is manufactured under ISO-aligned controls with batch COA traceability, supplying cosmetic formulators direct factory pricing and flexible kilogram-to-tonne bulk volumes for aqueous rinse-off systems.

This isothiazolinone biocide inactivates microbial enzymes via sulfhydryl-group interaction—delivering rapid bactericidal and yeast control at low ppm levels in shampoos, body washes, and wet-wipe rinse-off bases where water activity supports spoilage.

Unlike methylchloroisothiazolinone blends or phenoxyethanol-only systems, this CosIng-listed MIT suits rinse-off preservation portfolios where formulators want titrimetric assay traceability and EU Annex V–aligned low-dose use levels.

Product Specification

• INCI Name: Methylisothiazolinone
• CAS No.: 2682-20-4
• Appearance: Clear, pale yellow liquid (Typical)
• Solubility: Readily soluble in water and lower alcohols (Typical)
• Suggested pH: Effective pH 3–8; optimal below pH 8 (Typical)
• Assay Method: HPLC or iodometric assay (Typical)
• Shelf Life: 24 months sealed, 2–25°C (Typical)
• Standard Packaging: 1 kg / 25 kg
• Storage: Keep sealed, cool, dry, away from strong reducing agents (Typical)
• Regulatory Status: Listed in CosIng and EU Annex V; max 0.0015% in rinse-off products (EU); leave-on restricted
• Quality & Testing: Typical COA covers assay, related substances, and heavy metals
• Compliance Note: For cosmetic use only; not permitted in EU leave-on products; label when used per regional rules

Key Benefits & Applications

Methylisothiazolinone supports broad-spectrum microbial control and rinse-off formula stability through low-dose isothiazolinone activity suited to shampoo and cleanser formulators.

• Anti-Bacterial Activity: Inactivates bacterial enzymes via sulfhydryl interaction in aqueous shampoos, body washes, and wet-wipe bases.
• Yeast & Mold Control: Helps prevent fungal spoilage in high-water-activity rinse-off cleansing and hair-care systems.
• Acne Control Support: Preserves microbiological integrity of rinse-off blemish cleansers and facial wash-off formulas.
• Body Care System Stability: Extends shelf life of shower gels and liquid body soaps at permitted low ppm levels.

Formulation Guidelines

Add MIT to the aqueous phase at low ppm; confirm regional Annex V limits and rinse-off-only restrictions before scale-up.

• Recommended use level: 0.0005–0.0015% w/w (5–15 ppm) in rinse-off products (Typical, region-dependent).
• Optimal formula pH: Maintain pH 3–8; activity decreases above pH 8 (Typical).
• Processing: Add below 40°C to water phase; pre-dilute in water before combining with surfactant systems.
• Compatibility: Compatible with most anionic and amphoteric surfactants; avoid strong reducing agents and thiol-containing actives.
• Caution: EU restricts to rinse-off only at max 0.0015%; known sensitizer—conduct patch testing and label accordingly.
• Synergy: Layer Phenoxyethanol at 0.5–1% with MIT in rinse-off shampoos for stacked Gram-negative and yeast preservation.