Paeonol

Product Description

Green Stone Swiss manufactures Paeonol as a high-purity, single-compound phenolic for professional skincare brands that specify a defined HPLC assay. Production follows GMP-aligned controls, with batch documentation, COA support, and free samples for formulation trials. Direct factory supply covers routine bulk orders, backed by technical support from the manufacturing site.

Paeonol (CAS 552-41-0; 1-(2-hydroxy-4-methoxyphenyl)ethanone) is a methoxy-substituted acetophenone first identified in moutan root bark and now supplied as a single-compound cosmetic ingredient. Published studies report inhibition of tyrosinase activity and down-regulation of inflammatory mediators, while the phenolic structure supports free-radical scavenging. In the EU CosIng inventory its declared functions are antioxidant and skin conditioning, which aligns with soothing, tone-evening, and oxidation-sensitive leave-on systems.

Formulators use Paeonol in serums, emulsions, essences, and masks where a low-dose phenolic can sit beside niacinamide or other brightening actives. Limited water solubility is managed by pre-dissolution in ethanol or glycols, and the melting point near 50°C calls for cool-down addition. For procurement teams, a typical HPLC assay, stable solid form, and technical support simplify scale-up from bench to production.

Product Specification

• INCI Name: Paeonol
• CAS No.: 552-41-0
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.17 Da
• Appearance: White to off-white crystalline powder
• Purity: Typical ≥98% (HPLC)
• Solubility: Soluble in ethanol and glycols; limited solubility in water; dispersible in cosmetic oils
• Suggested pH: 4.0–7.0
• Storage: Store below 25°C in a cool, dry place; protect from light and moisture

Key Benefits & Applications

Paeonol is a defined phenolic active used in soothing and tone-evening systems where formulators need a specified assay and predictable dose response.

• Supports down-regulation of inflammatory mediators in sensitive-skin and redness-prone care
• Reported tyrosinase inhibition for tone-evening serums and creams
• Phenolic structure contributes free-radical scavenging in oxidation-sensitive formulas
• Suitable for serums, emulsions, essences, and treatment masks
• Suggested use level: 0.05–0.5% after pre-dissolution in ethanol or glycols

Formulation Guidelines

Pre-dissolve Paeonol and add it on cool-down to protect the low-melting phenolic and keep it evenly dispersed.

• Suggested Use Level: 0.05–0.5% in the finished formula
• pH Range: 4.0–7.0; avoid strongly alkaline conditions that can discolor phenols
• Addition: Dissolve in ethanol or a glycol, then add below 40°C during cool-down
• Compatibility: Compatible with niacinamide and common emulsifiers; avoid strong oxidizing agents
• Combine with Niacinamide for tone-evening and barrier support in the same leave-on system.