Pantethine

Product Description

Our high-purity Pantethine is manufactured under ISO-aligned controls with batch COA traceability, supplying cosmetic formulators direct factory pricing and flexible kilogram-to-tonne bulk volumes for aqueous skin and scalp care systems.

As a pantetheine dimer and coenzyme A pathway intermediate, pantethine supports acyl-transfer reactions in fatty acid synthesis and stratum corneum lipid renewal—mechanisms linked to sebum balance, barrier recovery, and anti-inflammatory comfort in serums and emulsions.

Unlike panthenol pro-vitamin forms or free pantothenic acid, this CosIng-listed pantethine suits oil-control and barrier-repair portfolios where formulators want HPLC-verified assay and direct factory supply with CoA-pathway specificity.

Product Specification

• INCI Name: Pantethine
• CAS No.: 16816-67-4
• Appearance: White to off-white crystalline powder (Typical)
• Solubility: Soluble in water; sparingly soluble in ethanol (Typical)
• Suggested pH: 5.5–7.5 in aqueous systems (Typical)
• Assay Method: HPLC or titrimetric purity assay (Typical)
• Shelf Life: 24 months sealed, below 25°C (Typical)
• Standard Packaging: 1 kg / 25 kg
• Storage: Keep sealed, cool, dry; protect from moisture and heat (Typical)
• Regulatory Status: Listed in CosIng as Pantethine; INCI recognized
• Quality & Testing: Typical COA covers assay, related substances, and heavy metals
• Compliance Note: For cosmetic use only; hygroscopic—seal promptly after opening to maintain assay stability

Key Benefits & Applications

Pantethine supports sebum-balancing, barrier-repair, and anti-aging claims through CoA-pathway activity suited to oily-skin and sensitive-skin formulators.

• Sebum Regulation: CoA-linked lipid metabolism helps manage excess surface oil in mattifying toners and oil-control serums.
• Skin Barrier Repair: Supports CoA-dependent fatty acid synthesis for stratum corneum barrier recovery in repair creams.
• Lipid Replenishment: Pantetheine pathway activity aids lipid renewal in post-treatment and sensitive-skin emulsions.
• Anti-Inflammatory Modulation: Calms irritation in blemish-prone and reactive oily-skin daily-care systems.
• Antioxidant Protection: Helps neutralize oxidative stress in daytime antioxidant and pollution-defense formulas.
• Anti-Aging Defense: Supports barrier-matrix integrity in mature-skin treatment lines targeting lipid-depleted skin.

Formulation Guidelines

Dissolve pantethine in the aqueous phase; confirm assay, pH, and hygroscopic handling protocols before scale-up.

• Recommended use level: 0.5–3% w/w in serums and emulsions; 0.5–2% in scalp tonics (Typical).
• Optimal formula pH: Maintain 5.5–7.5; best stability in near-neutral aqueous systems (Typical).
• Processing: Add to water phase at 25–40°C; pre-dissolve in warm water for clear serums.
• Compatibility: Works with niacinamide, panthenol, and ceramides; avoid prolonged high-heat above 80°C.
• Caution: Hygroscopic powder—minimize air exposure during weighing and transfer operations.
• Synergy: Pair Niacinamide at 2–5% with pantethine in oil-control barrier serums for dual sebum and CoA pathway support.