sh-Polypeptide-3

Product Description

Green Stone Swiss supplies cosmetic-grade sh-Polypeptide-3 under a direct factory model, with GMP-aligned quality control, batch documentation, and sample support for premium peptide and renewal skincare formulators.

sh-Polypeptide-3 (INCI: sh-Polypeptide-3; CAS 148348-15-6) is a single-chain recombinant human peptide produced by fermentation (typically in E. coli), based on keratinocyte growth factor (KGF / FGF-7). CosIng lists skin-conditioning function. In leave-on systems it is positioned for epidermal renewal, barrier-support, and anti-aging serum concepts that need a targeted growth-factor signal.

Regulatory note (preview): This INCI is not listed in China’s Inventory of Existing Cosmetic Ingredients (IECIC 2021) and is generally treated as a new cosmetic ingredient for China market use. Confirm destination-market rules before commercialization.

Product Specification

• INCI Name: sh-Polypeptide-3
• CAS No.: 148348-15-6
• Sequence: Recombinant human KGF (FGF-7), ~163 aa; full sequence Available upon request
• Molecular Formula: N/A
• Molecular Weight: ~18.9 kDa Typical (grade-dependent)
• Purity (HPLC): ≥95% Typical (COA Available upon request)
• Appearance: White to off-white lyophilized powder Typical
• Solubility: Soluble in water / aqueous buffers; confirm carrier system on COA
• Storage: Store sealed at low temperature as specified on COA; protect from light; avoid repeated freeze–thaw

Key Benefits & Applications

sh-Polypeptide-3 is a recombinant KGF peptide for professional renewal and barrier-support skincare systems.

• Supports CosIng skin-conditioning positioning in premium leave-on serums and ampoules
• Used in epidermal-renewal and anti-aging concepts linked to keratinocyte-focused signaling
• Fits barrier-recovery narratives after stress or procedure-adjacent cosmetic care (non-drug claims)
• May be screened in scalp/hair-care concepts where KGF-pathway storytelling is required
• Typical use level: Formulation-dependent; usually very low active levels—finalize by activity assay, stability, and finished-product assessment

Formulation Guidelines

Use these notes to keep sh-Polypeptide-3 active and stable in aqueous peptide systems.

• Suggested Use Level: Formulation-dependent; recombinant growth-factor peptides are typically used at low levels—confirm with activity data for the supplied grade
• Phase: Add to the water phase at cool-down; avoid prolonged high heat
• Stability: Protect from oxidation, proteases, and repeated freeze–thaw; consider chelators and suitable preservatives
• Delivery: Compatible with humectant serums; encapsulation or protective vehicles Available upon request for sensitive chassis
• Claims: Keep cosmetic skin-conditioning / renewal wording; do not use unauthorized drug or wound-treatment claims
• Combine with Palmitoyl Tripeptide 38 for complementary dermal matrix support alongside epidermal KGF signaling in anti-aging serums.