Subtilisin

Product Description

Subtilisin, also known as Alkaline Protease, is a high-performance proteolytic enzyme widely used in cosmetic formulations for gentle enzymatic exfoliation and skin renewal. Manufactured under strict quality control standards and supplied directly from the factory, our cosmetic-grade Subtilisin offers high enzymatic activity, consistent quality, and reliable performance for skincare manufacturers worldwide.

Subtilisin works by selectively hydrolyzing keratin proteins that bind dead skin cells to the skin surface, promoting natural exfoliation without the abrasive action associated with physical scrubs or the potential irritation of strong chemical exfoliants. This enzymatic process helps reveal smoother, brighter, and more refined skin while improving the absorption of subsequent skincare ingredients.

With increasing consumer demand for gentle exfoliation and microbiome-friendly skincare, Subtilisin has become a preferred active ingredient in enzyme peels, exfoliating cleansers, facial masks, and skin renewal treatments. Its mild yet effective exfoliating mechanism makes it suitable for formulations targeting dull, rough, and uneven skin.

Product Specification

• CAS No.: 9014-01-1
• INCI Name: Subtilisin
• Synonyms: Alkaline Protease
• Enzyme Class: Serine Protease
• Purity: ≥98%
• Appearance: White to Light Yellow Powder
• Solubility: Soluble in Water
• Suggested pH: 5.5–8.0 (Depending on Formulation)
• Storage: Store at 2–8°C in a Cool, Dry, Light-Protected Environment
• Properties: Enzymatic Exfoliation, Keratin Hydrolysis, Skin Renewal
• Origin: China

Key Benefits & Applications

Subtilisin is an effective cosmetic enzyme designed to provide gentle exfoliation while improving overall skin texture and radiance.

• Gentle Enzymatic Exfoliation: Removes accumulated dead skin cells without abrasive particles.
• Keratin Breakdown: Hydrolyzes keratin proteins to support natural skin renewal.
• Skin Texture Improvement: Helps refine rough skin and promote a smoother complexion.
• Enhanced Skin Radiance: Encourages brighter and more even-looking skin.
• Improved Ingredient Absorption: Exfoliation helps optimize penetration of subsequent skincare actives.
• Suitable for Sensitive Exfoliation Systems: Offers a milder alternative to many acid-based exfoliating ingredients.
• Wide Cosmetic Applications: Ideal for enzyme peels, exfoliating cleansers, facial masks, exfoliating powders, and skin renewal treatments.

Formulation Guidelines

Subtilisin is an enzymatic active ingredient that requires appropriate formulation conditions to preserve enzymatic activity throughout manufacturing and storage.

• Recommended Dosage: 0.05%–1.0%, depending on product type and desired exfoliating performance.
• Addition Method: Add during the cooling phase below 40°C to minimize enzyme deactivation.
• Recommended pH: Maintain formulation pH between 5.5 and 8.0.
• Compatibility: Compatible with humectants, amino acids, panthenol, allantoin, and soothing botanical extracts.
• Avoid: High processing temperatures, strong oxidizing agents, and extreme acidic or alkaline conditions that may reduce enzyme activity.
• Storage Recommendation: Store in airtight containers under cool, dry conditions away from heat and moisture.
• Synergy: Combines well with Papain or Bromelain to create multifunctional enzyme exfoliation systems with enhanced skin renewal performance.