Superoxide Dismutase

Product Description

Superoxide Dismutase (SOD) is a primary metalloenzyme and one of the most powerful antioxidants available to formulators. It represents the body's essential first line of defense against oxidative stress. Unlike secondary antioxidants (like vitamins) that merely scavenge downstream free radicals, SOD functions at the absolute source of damage. Its unique, specialized role is to neutralize the highly reactive superoxide anion (O₂⁻•)—the "spark" that ignites the entire oxidative damage cascade—converting it into less harmful molecules. By stopping this cascade before it begins, SOD prevents cellular breakdown and environmental damage. For manufacturers, incorporating SOD signals a commitment to high-performance, preventative, and biologically-advanced anti-aging solutions.

Product Uses

SOD's unique "first-defense" mechanism makes it an essential active for high-performance anti-aging and environmental protection lines. It is the core ingredient in serums and creams focused on "anti-pollution," "blue light defense," and "urban-aging," as these stressors are major generators of superoxide anions. It is also highly valued in advanced sun-care and after-sun formulations to mitigate the primary oxidative burst from UV exposure. For sensitive skin applications, its potent anti-inflammatory properties help to reduce redness and irritation, making it a powerful addition to calming and barrier-repair products.

Formulation Suggestions

SOD is a delicate enzyme, and its stability is the primary formulation challenge. It is extremely sensitive to heat; all incorporation must be done in the final cool-down phase, with temperatures strictly below 40°C (104°F). It performs optimally in a pH range of 5.0 to 7.5. For aqueous systems, a robust chelation system (e.g., EDTA) is recommended to protect the enzyme's metal co-factors from being displaced. For maximum stability and delivery, encapsulation (e.g., liposomes) or formulation in anhydrous (water-free) systems is highly advised. Our recommendations are for reference only; please follow the advice of your formulator for actual production.

Product Specification

• INCI Name: Superoxide Dismutase
• Synonyms: SOD, Orgotein
• CAS No.: 9054-89-1
• Molecular Formula: Metalloenzyme
• Appearance: Light blue to off-white powder
• Purity: ≥98%
• Solubility: Soluble in water. Insoluble in oils and ethanol.
• Stability: Stable as dry powder. Highly sensitive to heat (>45°C) and pH extremes in solution.
• Properties: Primary Antioxidant, Anti-aging, Anti-inflammatory, Environmental Protection
• Origin: China