Andrographolide

Product Description

Andrographolide is a high-purity, potent active derived from the traditional plant *Andrographis paniculata*. Renowned as the "King of Bitters," this diterpene lactone is a cornerstone of TCM for its powerful purifying and "cooling" properties. Its key advantage is its potent, multi-pathway anti-inflammatory action, making it a premier solution for calming redness and irritation. As the C-Beauty trend gains global traction, Andrographolide is emerging as the go-to, science-backed botanical for formulators developing high-performance, purifying products for blemish-prone and stressed skin.

Product Uses

This active is ideal for high-efficacy, purifying, and dermo-cosmetic formulations:

• Problem Skin: The perfect hero ingredient for anti-acne spot treatments, purifying serums, and clearing masks to target blemishes and inflammation.
• Soothing Formulations: Used in calming lotions and balms to reduce redness and soothe "heated" or irritated skin conditions.
• Scalp Care: Incorporated into purifying scalp tonics to help manage inflammation and microbial imbalance.

Formulation Suggestions

The recommended dosage is between 0.1-0.5%. As a powder with poor water solubility, Andrographolide must be pre-dissolved in a suitable solvent system, such as a blend of glycols (e.g., propanediol) or ethanol, before being added to a formulation. It is best incorporated during the cool-down phase (<40°C). It pairs well with other anti-acne actives like Salicylic Acid or Niacinamide.

Our advice is for reference only. Please follow the recommendations of your formulator for actual production.

Product Specification

• INCI Name: Andrographolide
• Synonyms: Diterpene lactone, King of Bitters
• CAS No.: 5508-58-7
• Molecular Formula: C₂₀H₃₀O₅
• Appearance: White crystalline powder
• Purity: ≥98%
• Solubility: Soluble in ethanol and glycols. Insoluble in water.
• Stability: Stable in solid form. In formulations, protect from strong light and extreme pH values.
• Properties: A potent diterpene lactone with strong, multi-pathway anti-inflammatory and skin-purifying (antimicrobial) properties. It helps to soothe irritation, reduce blemishes, and acts as a powerful antioxidant.
• Origin: China