Decarboxy Carnosine HCl

Product Description

Direct factory supply of high-purity Decarboxy Carnosine HCl—a decarboxylated carnosine analog (carcinine) synthesized under peptide-grade controls with batch COA traceability. This enzymatically stable pseudodipeptide supports cosmetic brands targeting glycation-related skin aging.

Unlike standard L-carnosine, decarboxylation enhances resistance to carnosinase hydrolysis while enabling carbonyl quenching and competitive inhibition of advanced glycation end-product (AGE) formation on collagen. The active also neutralizes ROS and lipid peroxidation byproducts that drive dermal fiber cross-linking (Typical).

Compared with first-generation carnosine, this HCl salt form offers improved aqueous solubility at pH 5.0–7.0—ideal for anti-glycation serums, firming eye treatments, and longevity-focused essence lines addressing stiffness, wrinkles, and glycation yellowing.

Product Specification

• INCI Name: Decarboxy Carnosine HCl
• CAS No.: 57022-38-5
• Sequence: β-Alanylhistamine (decarboxylated carnosine analog) (Typical)
• Molecular Formula: C6H15Cl2N4O (Typical)
• Purity (HPLC): ≥98% (Typical)
• Extraction Ratio: N/A — not applicable (Typical)
• Appearance: White to off-white crystalline powder (Typical)
• Solubility: Readily soluble in water; suitable for aqueous serums (Typical)
• Suggested pH: 5.0–7.0 in finished formulas (Typical)
• Assay Method: HPLC purity; titration for dihydrochloride salt (Typical)
• Shelf Life: 24 months sealed, 2–8°C (Typical)
• Standard Packaging: 1 kg, 5 kg, 25 kg sealed containers
• Storage: Store sealed, cool and dry; protect from moisture and light
• Regulatory Status: INCI listed as Decarboxy Carnosine HCl; indexed in CosIng
• Quality & Testing: HPLC purity, microbial limits, heavy metals Typical; COA per batch
• Compliance Note: For cosmetic use only; not for food, injectable, or pharmaceutical applications

Key Benefits & Applications

This enzymatically stable carnosine derivative targets glycation, oxidative stress, and dermal fiber integrity in advanced anti-aging skincare.

• Competitive AGE inhibition and carbonyl scavenging to protect collagen from glycation cross-linking.
• Broad-spectrum antioxidant defense against ROS and lipid peroxidation byproducts in aging skin.
• Anti-wrinkle and elasticity support via preserved dermal fiber integrity in firming serums.
• Collagen matrix protection against oxidative and glycation-induced cross-linking in anti-aging care.
• Anti-inflammatory modulation of NF-κB-related cytokine signaling in sensitive anti-aging routines.
• Even tone and radiance by limiting glycation-induced yellowing and oxidative dullness.

Formulation Guidelines

Typical use levels and compatibility notes for Decarboxy Carnosine HCl in anti-glycation and firming systems.

• Recommended use level: 0.5–2% w/w in serums and creams; 1–1.5% in targeted eye and neck treatments (Typical).
• Add during cool-down below 45°C; pre-dissolve in water phase before emulsion incorporation.
• Compatible pH 5.0–7.0; stable with most humectants, peptides, and barrier-repair actives.
• Water-soluble; suitable for aqueous essences, gel-creams, and light emulsions.
• Avoid prolonged exposure to strong oxidizers; patch-test with high-level metal chelators in single-pot systems.
• Synergy: Layer Ergothioneine with decarboxy carnosine at 0.5–1% for stacked carbonyl-quenching and mitochondrial antioxidant defense in anti-glycation serums.