Hexamidine Diisethionate

Product Description

Our high-purity Hexamidine Diisethionate is manufactured under ISO-aligned controls with batch COA traceability, supplying cosmetic formulators direct factory pricing and flexible kilogram-to-tonne bulk volumes for aqueous scalp and body care systems.

This bis-amidine salt disrupts microbial cell membrane integrity—effective against Malassezia yeast, Cutibacterium acnes, and odor-forming bacteria—enabling dual preservative and active anti-dandruff, sebum-control, and deodorant claims in shampoos, tonics, and rinse-off cleansers.

Unlike phenoxyethanol-only preservation or restricted legacy biocides, this CosIng-listed diisethionate salt suits clean-label scalp and body portfolios where formulators want water-soluble cationic antimicrobial activity with titrimetric assay traceability.

Product Specification

• INCI Name: Hexamidine Diisethionate
• CAS No.: 659-40-5
• Appearance: White to off-white crystalline powder (Typical)
• Solubility: Readily soluble in water; sparingly soluble in ethanol (Typical)
• Suggested pH: 5.0–7.0 in finished formulas (Typical)
• Assay Method: HPLC or non-aqueous titration (Typical)
• Shelf Life: 24 months sealed, below 25°C (Typical)
• Standard Packaging: 1 kg / 25 kg
• Storage: Keep sealed, cool, dry, and protected from moisture (Typical)
• Regulatory Status: Listed in CosIng and EU Annex V as preservative; max 0.1% in ready-to-use products (Typical)
• Quality & Testing: Typical COA covers assay, isethionate content, heavy metals, and microbial limits
• Compliance Note: For cosmetic use only; observe regional concentration limits—EU Annex V max 0.1% as preservative

Key Benefits & Applications

Hexamidine Diisethionate supports antimicrobial, anti-dandruff, and scalp-comfort claims through water-soluble bis-amidine activity suited to shampoo and rinse-off formulators.

• Anti-Bacterial Activity: Disrupts microbial cell membranes in aqueous shampoos, body washes, and deodorant base systems.
• Anti-Dandruff Support: Helps control Malassezia-linked flaking in anti-dandruff shampoos and leave-on scalp tonics.
• Acne Control Support: Supports antimicrobial action in rinse-off blemish cleansers and back-acne body wash formulas.
• Sebum Regulation: Helps manage oily scalp surface feel in daily clarifying shampoos and scalp balancing tonics.
• Scalp Soothing: Supports comfort in irritation-prone, dandruff-affected scalp care alongside conditioning agents.

Formulation Guidelines

Dissolve hexamidine diisethionate in the aqueous phase; confirm assay, pH, and regional Annex V concentration limits before scale-up.

• Suggested use level: 0.05–0.1% w/w in leave-on scalp products; up to 0.1% as preservative (Typical, region-dependent).
• Processing: Add to water phase at 25–40°C; pre-dissolve in warm water before combining with surfactant systems.
• pH window: Maintain 5.0–7.0; activity decreases in strongly alkaline systems (Typical).
• Compatibility: Compatible with most anionic and amphoteric surfactants; screen with strong anionic polymers in clear gels.
• Regulatory note: EU Annex V caps at 0.1% in finished products—do not exceed permitted preservative limits.
• Synergy: Layer Salicylic Acid at 0.5–1% with hexamidine in clarifying anti-dandruff scalp tonics for dual keratolytic and antimicrobial action.