Nisin

Product Description

Direct factory supply of high-purity Nisin (INCI: NISIN), a 34-amino-acid lantibiotic bacteriocin from Lactococcus lactis fermentation with potency-verified batches and COA traceability for bulk cosmetic sourcing.

This polycyclic peptide inhibits Gram-positive spoilage and pathogenic bacteria via peptidoglycan disruption, including Staphylococcus aureus and Cutibacterium acnes, with peak stability in acidic pH 3.5–5.0 aqueous systems.

Formulators deploy nisin as a natural antimicrobial aid in creams, acne gels, scalp treatments, and preservative-reduced lines—often paired with chelators or co-preservatives to broaden spectrum per ISO 11930 challenge protocols.

Product Specification

• INCI Name: NISIN
• CAS No.: 1414-45-5
• Sequence: 34-aa lantibiotic; nisin A isoform (Typical)
• Molecular Formula: C143H228N42O37S7 (Typical)
• Purity (HPLC): ≥900 IU/mg potency (Typical)
• Extraction Ratio: N/A — Lactococcus lactis fermentation (Typical)
• Appearance: White to creamy-white powder
• Solubility: pH-dependent; best in acidified aqueous systems (Typical)
• Suggested pH: 3.5–5.0 for maximum activity (Typical)
• Assay Method: Agar diffusion potency assay vs reference strain (Typical)
• Shelf Life: 24 months sealed, 4–15°C (Typical)
• Standard Packaging: 500 g / 1 kg / 25 kg sealed containers
• Storage: Cool, dry, dark; protect from moisture and heat
• Regulatory Status: INCI listed as NISIN; food additive E234 in select categories
• Quality & Testing: Potency, moisture, heavy metals, microbial limits per Typical COA
• Compliance Note: For cosmetic use only; perform ISO 11930 challenge testing; status varies by market

Key Benefits & Applications

Nisin lantibiotic peptide delivers selective Gram-positive antimicrobial control for natural preservation, acne care, and scalp-focused cosmetic formulations.

• Gram-Positive Antimicrobial Control: Disrupts peptidoglycan synthesis in Staphylococcus and related spoilage bacteria.
• Acne-Associated Bacteria Inhibition: Targets Cutibacterium acnes and S. aureus in low-pH acne gel and spot-treatment systems.
• Natural Preservative Support: Enables reduced synthetic preservative loading in aqueous creams and essences.
• Scalp Microbial Balance: Supports clean-scalp claims in rinse-off shampoos and treatment lotions.
• Microbiome-Friendly Selectivity: Bacteriocin action offers targeted control versus broad-spectrum biocides in sensitive-skin lines.

Formulation Guidelines

Formulate Nisin in acid-stable aqueous systems where natural Gram-positive antimicrobial control or preservative reduction is required.

• Use 100–500 ppm (0.01–0.05%) as starting level; adjust per ISO 11930 challenge test results.
• Maintain pH 3.5–5.0 for maximum potency; avoid prolonged exposure above pH 6.5.
• Pre-dissolve in acidified water or glycerin; add below 50°C in emulsion cool-down phase.
• Limited vs molds and Gram-negative bacteria; combine with chelators or co-preservatives as needed.
• Suitable for acne serums, scalp lotions, natural creams, and preservative-reduced topical systems.
• Synergy: Pair Niacinamide at 2–4% with nisin in pH 4.5 acne gels for barrier-friendly antimicrobial care.