Phytosphingosine

Product Description

As a dedicated wholesale supplier of Lipids & Terpenes, GSS offers High Purity Phytosphingosine at factory-direct prices. Phytosphingosine is a skin-identical sphingolipid produced through advanced bio-fermentation processes. Unlike surface-level moisturizers, it serves as a fundamental precursor that triggers the endogenous synthesis of ceramides within the stratum corneum. Beyond its structural role, it exhibits potent antimicrobial and anti-inflammatory biological activities, making it a critical active for multi-functional dermo-cosmetics. We provide high-quality bulk supply with comprehensive technical support for global formulators targeting barrier restoration and acne-prone skin management.

Product Specification

• INCI Name: Phytosphingosine
• Chemical Name: (2S,3S,4R)-2-Amino-1,3,4-octadecanetriol
• Synonyms: Sphingolipid Precursor, D-ribo-Phytosphingosine
• CAS No.: 554-62-1
• Molecular Formula: C1839NO3
• Molecular Weight: 317.51 g/mol
• Appearance: White to off-white crystalline powder
• Purity (Assay): ≥98.0% (HPLC)
• Solubility: Soluble in ethanol and glycols (e.g., Propanediol); insoluble in water
• Grade: Cosmetic Grade
• Origin: China (Bio-fermentation Supply)

Key Benefits & Applications

• Endogenous Ceramide Booster: Stimulates the skin's natural production of ceramides, reinforcing the barrier from within to provide long-term resilience against environmental stress.
• Microbiome Balancing (Anti-Acne): Exhibits selective antimicrobial activity against Propionibacterium acnes and Staphylococcus aureus, effectively reducing breakouts while maintaining skin flora balance.
• Targeted Anti-Inflammatory Action: Significant reduction in skin redness and cytokine-induced irritation, making it ideal for compromised or hypersensitive skin types.
• Scalp Health Optimization: Regulates microbial overgrowth on the scalp to mitigate dandruff and soothe persistent itching.
• Applications: Advanced barrier repair serums, specialized acne treatments (adult acne), soothing post-procedure lotions, and therapeutic scalp care formulations.

Formulation Guidelines

• Recommended Dosage: 0.05% – 0.2% for general barrier support; up to 0.5% for intensive acne or scalp treatments.
• Incorporation: Lipophilic. Must be pre-dissolved in glycols (such as Pentylene Glycol or Propanediol) or ethanol with gentle heating (60°C – 80°C) until the solution is clear before adding to the oil phase or the cool-down phase of an emulsion.
• pH Stability: Optimal stability and activity are maintained within a pH range of 4.5 – 6.5.
• Compatibility/Stability Notes: Highly stable in solid form; in liquid formulations, protect from strong oxidizing agents and maintain controlled storage temperatures to prevent precipitation.
• Synergy: Combine with Ceramide NP for a comprehensive external/internal barrier repair system, or with Totarol for an advanced, plant-derived antimicrobial synergy targeting inflammatory acne.