Polyquaternium-51

Product Description

Polyquaternium-51 is a state-of-the-art biocompatible polymer modeled after the phospholipid structure of the human cell membrane. Often referred to as "biomimetic hyaluronic acid," it outperforms traditional moisturizers through its unique molecular structure. Unlike standard humectants that rinse away with water, Polyquaternium-51 anchors itself to the stratum corneum, forming a hydrogel "second skin" that resists wash-off. Studies indicate its moisture retention capacity is twice that of Hyaluronic Acid, particularly in low-humidity environments. This ability to create a durable, protective moisture barrier makes it an essential ingredient for repairing damaged skin barriers and reducing trans-epidermal water loss (TEWL) in sensitive or compromised skin.

Product Uses

Due to its exceptional "rinse-resistant" properties, Polyquaternium-51 is the gold standard for **wash-off formulations**. It is widely used in high-end cleansers, body washes, and shampoos to provide a conditioned, hydrated feel after rinsing, eliminating the "tight" sensation often associated with surfactants. In **leave-on skincare**, it serves as a premium film-former in serums and creams, offering long-lasting hydration and suppressing skin roughness. Additionally, its biocompatibility makes it a top choice for **contact lens solutions** (to enhance lubrication) and makeup products, where it improves wear-time and skin affinity.

Formulation Suggestions

Polyquaternium-51 is highly water-soluble and easy to incorporate into formulations. It should be added to the aqueous phase, preferably during the cool-down stage (below 50°C), although it demonstrates reasonable heat stability. It is compatible with non-ionic, anionic, and amphoteric surfactants, making it versatile for cleansing systems. For skincare emulsions, it can be added at the final stage. The recommended usage level is 0.05% to 5.0% (based on 5% active solution) or adjusted accordingly if using pure powder. Our recommendations are for reference only; please follow the advice of your formulator for actual production.

Product Specification

• INCI Name: Polyquaternium-51
• Synonyms: MPC Copolymer, 2-Methacryloyloxyethyl Phosphorylcholine Copolymer
• CAS No.: 125275-25-4
• Molecular Formula: Complex Copolymer
• Appearance: White powder or Clear viscous liquid
• Purity: ≥98% (Powder) or 5% (Solution)
• Solubility: Highly soluble in water. Insoluble in oils.
• Stability: Stable over a wide pH range (4.0-8.0). Heat stable up to 80°C.
• Properties: Biomimetic, Wash-resistant Hydration, Barrier Repair, Film-forming
• Origin: China