Glycyrrhetinic Acid

Product Description

Glycyrrhetinic Acid is the high-purity, potent aglycone (active core) derived from glycyrrhizic acid of the licorice root. It is a cornerstone ingredient in dermo-cosmetics, renowned for its powerful, corticosteroid-like anti-inflammatory and soothing properties, but without the associated side effects. Its key advantage is its science-backed ability to effectively calm irritation, reduce redness, and alleviate discomfort. For formulators seeking a high-performance, natural-derived active for intensive soothing and skin comfort, Glycyrrhetinic Acid is the premier, oil-phase compatible choice.

Product Uses

This potent active is ideal for high-performance dermo-cosmetic and soothing formulations:

• Soothing Formulations: The ideal hero ingredient for creams, lotions, and targeted treatments for sensitive, irritated, or allergy-prone skin.
• Problem Skin: A key component in anti-acne products to reduce inflammation and redness associated with blemishes.
• Post-Procedure/Sun Care: Used in recovery balms and after-sun products to calm the skin and minimize inflammatory responses.
• Oral Care: Incorporated into toothpastes for gum soothing benefits.

Formulation Suggestions

The recommended dosage is between 0.1-1.0%. Glycyrrhetinic Acid is a crystalline powder with very poor water solubility. It must be pre-dissolved in the oil phase, often requiring heating (e.g., above 80°C in esters or oils), or solubilized using solvents like ethanol or glycols before incorporation. Ensure complete dissolution to prevent recrystallization. It is often formulated alongside its water-soluble salt (Dipotassium Glycyrrhizate) or its oil-soluble ester (Stearyl Glycyrrhetinate) for broader applicability and enhanced stability.

Our advice is for reference only. Please follow the recommendations of your formulator for actual production.

Product Specification

• INCI Name: Glycyrrhetinic Acid
• Synonyms: Enoxolone, Licorice Aglycone
• CAS No.: 471-53-4
• Molecular Formula: C₃₀H₄₆O₄
• Appearance: White to off-white crystalline powder
• Purity: ≥98%
• Solubility: Soluble in ethanol, acetone, chloroform. Sparingly soluble in oils. Insoluble in water.
• Stability: Stable in solid form. Protect from strong light and extreme pH in formulations.
• Properties: A potent triterpene aglycone from licorice root. Provides powerful anti-inflammatory, soothing, and anti-irritant effects, structurally similar to corticosteroids but without side effects. Also shows antioxidant and potential brightening benefits.
• Origin: China